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Drug-Regulatable, Inducible Expression of Membrane-Bound Interleukin 12 (DRIM-IL-12) for Use in Adoptive Cell Therapy

National Institutes of Health Clinical Cell/Gene Therapy
Probability of Success

50% · grade B · Medium data confidence

Model PoS 50% (grade B, medium data confidence). Strongest signals: Data maturity, IP position. Biggest drag: Competitive whitespace.

Data maturity (22%) 80

Clinical; efficacy signal, clinical reference.

IP position (16%) 72

Patent filed/pending -- prosecution ongoing.

Modality feasibility (14%) 55

Cell/gene therapy -- high upside, heavy manufacturing and regulatory load.

Indication pull (14%) 79

Oncology, Immunology -- active buyer appetite.

Competitive whitespace (12%) 60

Crowded oncology field.

Translational evidence (12%) 78

Public evidence mentions: clinical, efficacy, patient, safety.

Licensing readiness (10%) 94

Listed as available for licensing; established tech-transfer office; 1 public source link(s).

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Cost to the next milestone, decisive data, relevant articles, and the partner-ready development plan for this asset.

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