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HLA-A*01:01 Restricted Human T Cell Receptor Recognizing the NRAS Q61K Hotspot Mutation

National Institutes of Health Early / Discovery Cell/Gene Therapy
Probability of Success

14% · grade C · Medium data confidence

Model PoS 14% (grade C, medium data confidence). Strongest signals: Indication pull, Competitive whitespace. Biggest drag: IP position.

Data maturity (22%) 41

Early / Discovery; human data.

IP position (16%) 30

Protection lapsed or abandoned -- verify freedom to operate.

Modality feasibility (14%) 55

Cell/gene therapy -- high upside, heavy manufacturing and regulatory load.

Indication pull (14%) 77

Oncology, Immunology -- active buyer appetite.

Competitive whitespace (12%) 78

Under-served segment; crowded oncology field; multi-modal differentiation.

Translational evidence (12%) 62

Public evidence mentions: human, patient.

Licensing readiness (10%) 94

Listed as available for licensing; established tech-transfer office; 1 public source link(s).

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