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TNF-R1 Selective Allosteric Inhibitors

University of Pennsylvania Preclinical Small Molecule
Probability of Success

25% · grade C · Medium data confidence

Model PoS 25% (grade C, medium data confidence). Strongest signals: Data maturity, Modality feasibility. Biggest drag: Competitive whitespace.

Data maturity (22%) 59

Preclinical; in vivo data.

IP position (16%) 45

No clear patent status in public data -- treat IP as unpriced until counsel confirms.

Modality feasibility (14%) 82

Small molecule -- well-trodden regulatory and CMC path.

Indication pull (14%) 77

Oncology, Immunology -- active buyer appetite.

Competitive whitespace (12%) 60

Crowded oncology field.

Translational evidence (12%) 62

Public evidence mentions: in vivo, patient.

Licensing readiness (10%) 94

Listed as available for licensing; established tech-transfer office; 1 public source link(s).

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