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Targeted modulation of noncoding BMPR2 sequences increases protein expression for treatment of pulmonary arterial hypertension

University of Pennsylvania Preclinical Biologic
Probability of Success

26% · grade C · Medium data confidence

Model PoS 26% (grade C, medium data confidence). Strongest signals: Data maturity, IP position. Biggest drag: Translational evidence.

Data maturity (22%) 58

Preclinical; clinical reference.

IP position (16%) 72

Patent filed/pending -- prosecution ongoing.

Modality feasibility (14%) 55

Cell/gene therapy -- high upside, heavy manufacturing and regulatory load.

Indication pull (14%) 70

Infectious Disease -- active buyer appetite.

Competitive whitespace (12%) 74

Multi-modal differentiation.

Translational evidence (12%) 62

Public evidence mentions: clinical, patient.

Licensing readiness (10%) 94

Listed as available for licensing; established tech-transfer office; 1 public source link(s).

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